International Workshop
"From Homo sapiens
to Homo sapiens liberatus"

25 May
Conference Hall 221, Bldg. "B"

9:15-9:45

Registration, coffee

9:45-12:00
Chairmen, G. Blobel*, A. Olovnikov

V.P. Skulachev	9:45-10:00	Introductory remarks
V.P. Skulachev and M.V. Skulachev	10:00-10:45	The present state of the art of the SkQ Megaproject
	10:45-11:00	Discussion
B. Cannon	11:00-11:15	Multiplicity of beneficial effects of mitochondrially targeted plastoquinone on ageing phenotype in premature ageing mice with increased mitochondrial DNA mutations
	11:15-11:30	Discussion
J. Nedergaard	11:30-11:45	Mitochondrial effects of prolonged treatment of mtDNA mutator mice with SkQ
	11:45-12:00	Discussion
	12:00-12:30	Coffee break

12:30-14:30
Chairmen, B. Cannon, V.I. Kapelko

D.B. Zorov	12:30-12:45	Effects of SkQs on oxidative stress-mediated injuries of kidney and brain
	12:45-13:00	Discussion
B.V. Chernyak	13:00-13:15	SkQ1 accelerates dermal wound healing in animals
	13:15-13:30	Discussion
N.G. Kolosova	13:30-13:45	Effects of SkQ on cataract and retinopathies in OXYS rats
	13:45-14:00	Discussion
A.A. Zamyatnin	14:00-14:15	Clinical trials of the SkQ1 drops in treatment of "dry eye"
	14:15-14:30	Discussion
	14:30-15:45	Lunch

15:45-19:15
Chairmen, J. Nedergaard, E.I. Rogaev

V.N. Anisimov	15:45-16:00	Effects of SkQ on lifespan and spontaneous carcinogenesis in female mice of three different strains
	16:00-16:15	Discussion
F.F. Severin	16:15-16:30	Two mechanisms of antioxidant activity of SkQs
	16:30-16:45	Discussion
D.A. Cherepanov	16:45-17:00	Possible role of the Complex III-bound cardiolipin dimer in initiation of mitochondrial lipid peroxidation
	17:00-17:15	Discussion
S.A. Nedospasov	17:15-17:30	Unexpected features in mice with mutant cytochrome c
	17:30-17:45	Discussion
	17:45-18:15	Coffee break
J. Mitteldorf	18:15-18:30	Darwinian Evolution is a Highly Evolved Process
	18:30-18:45	Discussion
V. Gorbunova	18:45-19:00	SIRT6 promotes DNA repair under stress by mono-ADP-ribosylating PARP1
	19:00-19:15	Discussion

19:15-20:15
Chairmen, G. Libertini, L. Gavrilov

A. Seluanov	19:15-19:30	Anticancer mechanisms in a longest-lived rodent, the naked mole-rat
	19:30-19:45	Discussion
H.S. Saunders	19:45-20:00	Non-senescence in classical evolutionary theory
	20:00-20:15	Discussion
	20:15	Coffee break

26 May
Conference Hall 221, Bldg. "B"

9:00-9:30

Coffee

9:30-12:00
Chairmen, C.J. Hauser, S.A. Nedospasov

K. Lewis	9:30-9:45	Examples of prokaryotic genetic programs detrimental to individual cell
	9:45-10:00	Discussion
N. Gavrilova	10:00-10:15	Comparative analysis of parameters of human ontogenesis and senescence
	10:15-10:30	Discussion
G. Libertini	10:30-10:45	Oxidative damage and aging (+ link to slides)
	10:45-11:00	Discussion
T. Goldsmith	11:00-11:15	Rationale for complex programmed life span regulation in mammals (+ links to full text and slides)
	11:15-11:30	Discussion
	11:30-12:00	Coffee break

12:00-14:00
Chairmen, T. Goldsmith, D. Vinogradov

E.I. Rogaev	12:00-12:15	Brain and aging
	12:15-12:30	Discussion
C.J. Hauser	12:30-12:45	Mitochondrial debris including mitochondrial DNA and formyl peptides that appear in the blood after major trauma can induce a syndrome resembling sepsis
	12:45-13:00	Discussion
A.G. Ryazanov	13:00-13:15	An enzyme whose inactivation delays aging and increases lifespan
	13:15-13:30	Discussion
	13:30-14:00	General discussion
	14:00-15:00	Lunch
POSTERS	15:00-16:00	N.A. Bocharova et al., Role of mitochondria in cell senescence-induced death of yeast Saccharomyces cerevisiae E.K. Fetisova et al., Induction of multidrug resistance P-glycoprotein inhibits the antiapoptotic action of mitochondria-targeted antioxidant SkQR1 L.A. Gavrilov & N.S. Gavrilova, Demographic Consequences of Defeating Aging E.N. Grigoryan et al., The novel antioxidant SkQ1 as an effective protector of rat eye tissues during long-term organotypic cultivation D.A. Knorre et al., Sir2-dependent daughter-to-mother transport of the damaged proteins in yeast is necessary to prevent high stress sensitivity of the daughters G. Libertini, Comparison between two paradigms about aging (+ link to poster) G. Libertini, Are C. elegans and D. melanogaster valid animal models for studies on aging? (+ link to poster) G. Libertini, Arguments against telomere-telomerase system as general defence against cancer (+ link to poster) G. Libertini, A proposal: Project "Homo sapiens liberatus II"! (+ link to poster) M. Vyssokikh et al. , Altered content and fatty acid composition in cardiolipin of mitochondria from mtDNA mutator mice L.S. Yaguzhinsky et al., The study of uncoupling action mechanism of SkQ?SkQ3 family compounds M.A. Kozlova & A.Y. Mulkidjanian, The impact of membrane-targeted cations on energy conversion in membrane vesicles from Rb. capsulatus E.V. Titova et al., The effect of mitochondria-targeted antioxidants on normal and transformed cells in culture G.S. Shagieva et al., The effects of mitochondria-targeted antioxidants on human cervical cancer cells in culture
Chairman, V.P. Skulachev	16:00-17:30	Discussion on initiation of the Homo sapiens liberatus (HSL) movement
G. Blobel*	17:30-17:45	Concluding remarks
	19:00-22:00	Banquet at a Moscow river boat (starts near Radisson Royal Hotel, former "Ukraina" Hotel)

* Off sick